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Posterior Fossa Syndrome

Also known as: Cerebellar mutism, Cerebellar mutism syndrome, Cerebellar cognitive affective syndrome, Transient cerebellar mutism, Mutism and subsequent dysarthria

What is Posterior Fossa Syndrome?

Posterior fossa syndrome, or cerebellar mutism, is a condition that sometimes develops after surgery to remove a brain tumor in the posterior fossa region of the brain. The posterior fossa is a space near the base of the skull that contains the cerebellum and brain stem.

Children with posterior fossa syndrome usually have a collection of symptoms. The most prominent symptom is limited or loss of speech. Although children lack expressive speech, they may be able to process and understand information. Other symptoms of posterior fossa syndrome include changes in speech, movement, emotions, and behavior.

Symptoms usually appear 1-10 days after tumor surgery and can last weeks or months. Even with improvement, patients may have some degree of ongoing problems.

Tumors in the posterior fossa region account for over half of all brain tumors in children. About 25% of children who have surgery to remove medulloblastoma, a posterior fossa tumor, will develop posterior fossa syndrome.

Tumors in the posterior fossa region account for over half of all brain tumors in children. About 25% of children who have surgery to remove medulloblastoma, a posterior fossa tumor, will develop posterior fossa syndrome.

Tumors in the posterior fossa region account for over half of all brain tumors in children. About 25% of children who have surgery to remove medulloblastoma, a posterior fossa tumor, will develop posterior fossa syndrome. Less commonly, surgery for other tumors, such as astrocytoma and ependymoma, may also cause posterior fossa syndrome.

Posterior fossa syndrome is not completely understood. Doctors don’t know exactly why this condition affects some children and not others. Although certain factors may increase the risk, posterior fossa syndrome cannot be predicted ahead of time. There is no known cure for posterior fossa syndrome, and the course of recovery varies widely.

Posterior fossa syndrome (also called cerebellar mutism) develops in about 25% of children who have surgery to remove medulloblastoma, a posterior fossa tumor. In this image, a young medulloblastoma patient plays a game with blocks.

Posterior fossa syndrome develops in about 25% of children who have surgery to remove medulloblastoma, a posterior fossa tumor.

Symptoms of posterior fossa syndrome range from mild to severe. Symptoms usually improve with time as the brain heals. Most children will regain the ability to communicate and walk independently. Recovery is usually a long process, occurring over weeks, months, or even years. Patients often have long-term problems in one or more areas of function, particularly gait, coordination, clarity of speech, and cognition. Children with more severe symptoms are more likely to have lasting deficits.

Care for posterior fossa syndrome usually includes a combination of rehabilitation services including physical therapy, occupational therapy, and speech therapy. Nutrition support, psychology, and school support are also important.

Common Symptoms of Posterior Fossa Syndrome

  • Loss of speech or mutism
  • Lack of muscle control or coordination
  • Abnormal eye movements
  • Emotional lability, irritability, or behavior changes
  • Trouble swallowing
  • Muscle weakness or low muscle tone
  • Temporary loss of voluntary movements
  • Cognitive problems
 

Symptoms of Posterior Fossa Syndrome

Posterior fossa syndrome is a collection of symptoms which include changes in speech, movement, emotions, behavior, and/or cognition.

Symptoms of posterior fossa syndrome are complex, and they are often related to one another. For example, children may become agitated and frustrated when they are unable to communicate. Speech and language impairments may have several causes, including muscle weakness, apraxia, and cognitive impairment. In addition, patients continue to receive cancer treatments that may cause additional problems, make symptoms worse, or delay recovery. However, it is important to know that most patients do have significant improvement in symptoms over time and become independent in activities of daily living.

Good supportive care and encouragement can help promote the best recovery possible.

Care for Children with Posterior Fossa Syndrome

Supportive care is the main treatment available for posterior fossa syndrome. Specific symptoms are addressed using a combination of therapies including: 

  • Speech Therapy
  • Physical Therapy
  • Occupational Therapy
  • Cognitive Assessment and Rehabilitation
  • Psychology and Behavior
  • School Support and Accommodations
  • Clinical Nutrition

Tips for Families Facing Posterior Fossa Syndrome

Get support. Posterior fossa syndrome can be especially challenging for patients and families. Parents feel helpless and frustrated when they can’t soothe or communicate with their child. As children begin to recover, they also report being frustrated that they were able to understand but could not communicate or express thoughts and feelings. It is hard for families to know what to expect or what to do to help their child. Other families who have been through a similar experience can be a source of support and advice. An experienced care team is also important to make sure patients and families have the resources they need for the recovery journey.

Manage expectations. Posterior fossa syndrome is very unpredictable. Recovery looks different for each patient, and each symptom can have a different time course. Although other families can be a source of help and encouragement, it is important to avoid setting expectations based on another patient’s journey.

Find information and ask questions. Posterior fossa syndrome is a rare condition. Many rehabilitation specialists have never worked with a child with the condition. Parents are important advocates for their child. They can work with the care team to make sure their child has appropriate specialists and support services, especially as the child transitions to outpatient or long-term care.

Questions to ask the care team about posterior fossa syndrome:

  • Does my child have any additional risk factors?
  • What should I watch for after surgery?
  • How will my child be monitored after surgery?
  • What treatments are available if my child shows symptoms of posterior fossa syndrome?
  • What can I do to help my child during recovery?

Use assistive devices and strategies as recommended by your care team. A variety of resources are available for patients and families to support communication, physical mobility, and activities of daily living.

A speech therapist may recommend the use of communication aids such as gestures, hand signals, sign language, and boards or devices to allow children to express wants and needs.

A physical therapist can help families make decisions about mobility equipment and help measure and fit patients with equipment such as a wheelchair, walker, cane, and/or leg braces. Patients often use many different types of equipment during their recovery. They may use some equipment for certain activities and not for others. For example, a child may use a walker to move around at home but will use a wheelchair for longer distances, such as going to the store or to school.

An occupational therapist may recommend specialized equipment to help with daily activities like bathing and using the restroom. Tools such as modified pencils and adapted feeding utensils may also be recommended to make tasks easier. In some cases, orthotics for the child’s hands may be prescribed to help the child with fine motor tasks.

Be patient with therapy. Patients and families may become frustrated when progress is hard to see. However, continuing therapy is important, even if progress seems slow. Ongoing monitoring and long-term support, including academic accommodations, can help promote quality of life after posterior fossa syndrome.


Reviewed: September 2018