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Chloditan; Chlodithane; Khloditan; Mytotan
Often used for:
Adrenocortical carcinoma, Cushing syndrome
Mitotane is a type of chemotherapy used to treat cancer of the adrenal gland. It works by slowing or stopping the growth of adrenocortical cells. It also lowers production of steroid hormones made in the adrenal gland. These hormones help to regulate important body functions. Patients will need steroid replacement therapy with fludrocortisone and hydrocortisone.
Patients will begin therapy with a low dose, which will be gradually increased. Patients will have regular blood draws to check the amount of mitotane in the blood. The dose of mitotane may change based on results of lab tests. Blood levels that are too high increase the risk of unwanted side effects.
Mitotane is stored in the body primarily in fat tissue. Because of this, it can take several weeks to reach high enough levels in the blood. It may also remain in the blood for months after the medication has been stopped as the drug is slowly eliminated from the body.
May be taken as a tablet by mouth
May be taken as a liquid by mouth
*These symptoms are usually associated with higher drug levels in the blood. Therapy will be held until symptoms improve and continued at a lower dose.
Not all patients who take mitotane will experience these side effects. Common side effects are in bold, but there may be others. Please report all suspected side effects to your doctor or pharmacist.
Be sure to discuss these and other recommendations with your doctor or pharmacist.