Cardiac late effects in childhood cancer survivors occur due to certain treatments.
Some childhood cancer treatments may cause heart problems after treatment ends. These are called cardiac late effects. Cardiac means "related to the heart."
Radiation to the chest and a type of called anthracyclines are the main causes of cardiac late effects.
Most childhood cancer survivors do not have heart problems due to cancer treatment.
Healthy habits such as physical activity and a heart-healthy diet can help you manage or prevent many heart conditions.
The heart is a muscular organ that pumps blood to the body’s organs. The heart is at the center of the circulatory system, which is made up of a network of blood vessels, such as arteries, veins, and capillaries.
Cardiac conditions that may occur include:
Cardiomyopathy can get worse over time. It can lead to heart failure.
Anthracyclines are medicines used to treat many types of cancer.
These medicines include:
Anthracyclines can damage the heart muscle (cardiomyopathy). This damage can include heart failure. The risk of developing this condition increases with the amount of medicine given (dosage).
Anthracycline dosage (cumulative) |
Risk of heart failure |
---|---|
Less than 100 mg/m2 |
Low |
More than 250 mg/m2 |
Moderate |
250 mg/m2 or greater | High |
Radiation given near the heart is a risk factor for heart disease. The risk increases with the amount of chest radiation given (dosage).
Radiation dosage |
Risk |
---|---|
<15 Gy |
Low |
15 Gy–<30 Gy |
Moderate |
30 Gy or more | High |
Survivors who had both anthracyclines and chest radiation have the highest risk.
At first, survivors may not have symptoms. But heart disease may be present.
An echocardiogram (echo) is an easy, non-invasive way to detect heart disease before symptoms develop. It uses sound waves to make images of the heart.
Heart tests such as an echocardiogram (echo) detect early signs of heart disease.
Patients may have:
Cancer survivors can do things to promote heart health:
Habits that promote heart health include:
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Reviewed: October 2023
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