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Methotrexate Sodium, MTX
Often used for:
Acute lymphoblastic leukemia, Brain tumors, Non-Hodgkin lymphoma, Osteosarcoma, Graft-versus-host disease
Methotrexate is a type of chemotherapy. It works by slowing or stopping the growth of cells. This medicine may be given in the clinic, hospital, or at home. The schedule and dose depends on the type of cancer, child’s age, and method of administration.
If children receive high doses of methotrexate, they may also be given extra IV fluids and a medicine called leucovorin to reduce side effects.
Patients will have regular blood draws to check blood counts, the amount of methotrexate in the blood (if very large doses are given), and monitor liver and kidney function. Methotrexate dose changes may occur based on levels in the blood.
May be taken as a tablet by mouth
May be given as a liquid by IV or injected into a muscle
May be given in the cerebrospinal fluid (intrathecal)
Not all patients who take methotrexate will experience these side effects. Common side effects are in bold, but there may be others. Please report all suspected side effects to your doctor or pharmacist.
Some patients may experience long-term or late effects of treatment that may continue or develop months or years after treatment ends. Possible late effects due to methotrexate include:
Be sure to discuss these and other recommendations with your doctor or pharmacist.