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Depression, sometimes known as clinical depression, major depression, or major depressive disorder, is one of the most common mental health disorders. A depressive disorder can develop at any age. Among children and teens, depression is more likely after puberty. Symptoms of depression include feeling sad, down, or hopeless, and loss of interest in hobbies or activities.
Occasional symptoms of depression are common for someone facing serious illness like pediatric cancer. However, in a depressive disorder, symptoms are more severe, longer lasting, and affect daily function. Clinical depression is a real illness, and patients need specialized treatment such as psychotherapy or antidepressant medicine.
Despite the stress of pediatric cancer, most patients do not develop clinical depression. But support for mental health can help all patients and families cope with negative thoughts and emotions. A mental health professional can help families understand symptoms of depression, know when symptoms indicate a more serious disorder, and find resources to meet patient and family needs.
Occasional thoughts or feelings of sadness or low mood are normal during the cancer journey. However, some patients may have more severe and longer lasting symptoms of depression that affect the way they feel, think, and act. Symptoms can vary, especially in children and teens. In a depressive disorder, symptoms are persistent and cause distress or problems in daily function.
Signs and symptoms of depression in children and teens may include:
Depression may look different in children and adolescents compared to adults. For example, children and adolescents may be more irritable, angry, anxious, or defiant. They may also express more physical complaints or engage in risky behaviors.
Symptoms of depression can occur at any stage of the cancer journey. Sometimes, depression can be confused with symptoms that occur due to physical illness or as a side effect of cancer treatments or medicines. An accurate diagnosis is important to determine the best approach to treatment. If a patient shows symptoms of depression, families may be referred to a mental health specialist for further evaluation. Psychologists, psychiatrists, social workers, counselors, and other mental health providers have special training to diagnose and treat mood disorders and other mental health concerns.
A serious illness, such as cancer, is a risk factor for depression. This means that pediatric cancer patients are at higher risk for depression compared to healthy peers. Having one or more risk factors does not mean that someone will develop depression. However, knowing risk factors can help families be more watchful and take steps to support mental health.
Risk factors that may contribute to depression in children and teens include:
A variety of other factors can affect mental health during the cancer journey. Treatments and procedures, pain, side effects, medicines, hormone changes, poor nutrition, sleep problems, and life disruptions can make it hard to cope. Patients may also struggle with accepting a “new normal” as they deal with long-term issues like physical limitations, body image, identity, ability to function at school or work, fertility, relationships, independence, and survival. In some patients, these factors may contribute to the development of depression.
Grief can be a risk factor for depression. During the cancer journey, many childhood cancer patients have to cope with losing a friend to cancer. For some children, this might be the first time to experience the loss of a loved one. This can also bring up negative thoughts and emotions about their own survival. However, having some symptoms of depression during bereavement does not mean a person has a depressive disorder. Each person has a unique experience of grief, so there is no true “normal.” But, there are some general differences between grief and depression.
Understanding the differences between grief and depression can help match support resources to patient and family needs.
A mental health professional uses specific guidelines to evaluate and diagnose mental health problems. During cancer, the diagnosis can be even more complex due to the effects of illness and treatments. Some of the more common disorders related to childhood depression include:
Managing symptoms of depression is important, whether or not a patient has a diagnosable disorder. Symptoms of depression can:
A depressive disorder can also occur along with other common mental health problems such as anxiety disorders, substance use disorders, and attention deficit hyperactivity disorder (ADHD).
Psychotherapy and antidepressant medicines are often first treatments for a depressive disorder. Each person responds differently to antidepressant therapy, and it may take some time for depression to improve.
During cancer, mental health care can be even more complex in the context of the many stressors and challenges that patients and families face. A multidisciplinary care team is important to make sure that patients receive appropriate treatment for depression in the context of cancer care and other medical needs.
Providers who offer mental health services for depression include:
Psychotherapy, or “talk therapy”, is a main treatment for depression. One of the most effective types of psychotherapy for depression is Cognitive Behavioral Therapy (CBT). CBT helps patients identify negative thoughts and behaviors and to react to situations in a more helpful way. Psychotherapy may also focus on developing skills to solve problems, improve relationships, or manage stress. Specific coping strategies such as relaxation or mindfulness techniques, art therapy, music therapy, and play therapy may be helpful for children and teens with depression. Psychotherapy can occur in a variety of settings including individual, group, or family therapy.
A doctor may prescribe medicine for depression. Antidepressants work over time to treat a depressive disorder. These medicines act on neurotransmitters thought to be involved in depression. Some patients may need a combination of medicines for full benefit.
Medicines used to treat depression in children and teens may include:
Patients taking antidepressants need regular doctor visits to make sure the medicines are working properly and to monitor any side effects. In rare cases, some medicines may prompt aggressive behavior or increase risk of suicide.
It is important to follow dosing instructions carefully. Patients should not take more than prescribed and should not stop taking the medicine without medical supervision. Be sure to let a doctor know if depression does not improve.
Questions to ask your doctor when prescribed an antidepressant medicine:
Specific cancer types and treatments may change the way the body responds to medications. It is possible that this may require using only certain antidepressant medications or even using less commonly prescribed medications for depression. Be sure to keep your full care team updated on any changes to your treatment plan or medications. Also, feel free to ask why a specific medication is being chosen if you have questions or concerns.
Medicines used to treat depression can be unsafe if taken more often or in greater amounts than prescribed or if stopped too quickly. Please ask your doctor before making any dose changes. Also, be sure to store medicines safely, and keep out of the reach of children.
Children and teens with depression should be monitored for suicide risk and worsening of symptoms. Patients often need ongoing therapy to prevent relapse of depression.
The rate of depression in childhood cancer survivors is about twice as high as in the general population. The reasons for the increased risk is not fully known. However, many survivors face lifelong challenges such as:
A comprehensive survivorship care plan that includes mental health follow-up and support is important for long-term wellbeing and quality of life after cancer.
Childhood cancer survivors can take steps to promote mental health:
Together does not endorse any branded product mentioned in this article.
Reviewed: April 2019