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Fludarabine

Chemotherapy

Brand names:

Fludara®

Other names:

Fludarabine phosphate

Often used for:

Leukemia, Lymphoma

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About fludarabine

Fludarabine is a type of chemotherapy. It works by slowing or stopping the growth of cells. It is also used to help prepare patients for allogeneic hematopoietic cell transplant.

Patients will have regular blood draws to check blood counts and monitor liver and kidney function.

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May be given as a liquid into a vein by IV

 
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May be taken as a tablet by mouth (not available in the U.S.)

 
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Possible side effects

  • Nausea and vomiting
  • Fever
  • Chills
  • Infections
  • Fatigue
  • Loss of appetite
  • Mouth sores 
  • Sweating
  • Muscle pain
  • Low blood counts (may cause increased risk of infection, bleeding, anemia, and/or fatigue)
  • Cough
  • Trouble breathing
  • Weakness
  • Headache
  • Vision changes
  • Confusion
  • Rash
  • Diarrhea
  • Bleeding (in urine or stool)
  • Tingling in the hands or feet
  • Swelling of feet or legs

Not all patients who take fludarabine will experience these side effects. Common side effects are in bold, but there may be others. Please report all suspected side effects to your doctor or pharmacist.

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Possible late effects

Some patients may experience long-term or late effects of treatment that may continue or develop months or years after treatment ends. Possible late effects include:

  • Neurologic disorder called ‘leukoencephalopathy’. Signs may include confusion, weakness, difficulty speaking, vision changes, or seizures.
  • Skin cancer
  • Fertility problems in males
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Tips for families

Be sure to discuss these and other recommendations with your doctor or pharmacist.

  • Sexually active patients should take steps to prevent pregnancy during treatment and for 6 months after completion of therapy.
  • Patients should tell their doctor if they are pregnant or breastfeeding.
  • Caregivers should follow instructions to avoid contact with patient body fluids, which can contain the drug for 48 hours after it is given.

Fludarabine resources

Learn More About Fludarabine

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Always check the medication label. Many medicines look the same. Do not take any new medicine, including over-the counter medicines or supplements, without checking with your doctor or pharmacist. Talk to your doctor or pharmacist about what to do in the case of a missed dose, allergic reaction, or medical emergency. 

This information is not intended to be a complete guide and is not a substitute for talking with your provider. Medicine names, appearance, formulas, or availability may vary by clinic location. Always follow the instructions given by your care team.