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Romiplostim

Thrombopoietic Agent

Brand names:

Nplate®

Often used for:

Immune thrombocytopenia (ITP), low platelet count

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What is romiplostim?

Romiplostim is a medicine used to help the blood clot and reduce bleeding. It works by increasing the platelet count. 

This medicine may be given in the hospital or clinic. It is usually given once a week. 

Romiplostim may increase the chance for blood clots if the platelet count is too high.  It is important to have regular blood draws to monitor platelet counts. 

Shot

May be given as a shot into a fatty part of the skin (subcutaneous injection)

 
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Possible side effects

  • Mild joint or muscle pain
  • Headache
  • Stomach pain
  • Diarrhea
  • Mouth or throat pain or irritation
  • Difficulty sleeping
  • Runny nose, congestion, cough or other cold symptoms
  • Fever
  • Skin rash 
  • Allergic reaction - Call your care team right away if your child has symptoms of an allergic reaction.  These may include:
    • Rash, hives, or itching 
    • Flu-like symptoms such as fever, chills, headache, or muscle ache
    • Dizziness
    • Shortness of breath, coughing, or tightness in the throat
    •  Low blood pressure, pain in the chest, side, or back, or swelling of the face or neck. 

Not all patients who take romiplostim will have these side effects. Common side effects are in bold, but there may be others. Please report all symptoms or side effects to your care provider or pharmacist.

Find more information on side effects.

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Tips for patients and families

Be sure to discuss all questions and instructions with your care provider or pharmacist. 

  • Do not miss injection appointments. If you cannot make it to an appointment, contact your care team right away to reschedule the appointment.
  • Your child may bleed more easily, and wounds may heal more slowly. Brush teeth gently with a soft toothbrush, use an electric razor to shave, and avoid activities that can cause injury.
  • Talk to your care provider before your child takes part in any contact sports or activities that may increase the risk for injury.
  • Tell all health care providers, including your dentist, that your child is receiving romiplostim treatment.
  • It is important that patients tell the care team if they are sexually active, pregnant, or breastfeeding.

Learn more about romiplostim

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Always check the medication label. Many medicines look the same. Do not take any new medicine, including over-the counter medicines or supplements, without checking with your doctor or pharmacist. Talk to your doctor or pharmacist about what to do in the case of a missed dose, allergic reaction, or medical emergency. 

This information is not intended to be a complete guide and is not a substitute for talking with your provider. Medicine names, appearance, formulas, or availability may vary by clinic location. Always follow the instructions given by your care team.

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Reviewed: April 2024