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Melatonin

Supportive Care

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What is melatonin? 

Melatonin is a hormone made in the brain during nighttime hours. It works by helping to regulate when you sleep and wake up.

Melatonin supplements can help your child fall asleep and sleep better. It is available over-the-counter (OTC) without a prescription.

This medicine may be given in the clinic, hospital or at home.

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May be given as a tablet or capsule by mouth 

 
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May be given as a liquid by mouth

 
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Possible side effects

  • Excessive sleepiness (drowsiness)
  • Diarrhea
  • Joint pain
  • Back pain
  • Stuffy nose

Not all patients who take megestrol acetate will experience these side effects. Common side effects are bolded, but there may be others. Please report all suspected side effects to your doctor or pharmacist.

Find more information on side effects.

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Tips for patients and families

Be sure to discuss all questions and instructions with your health care team. 

  • This medicine may work better for some patients than for others. 
  • It may make your child drowsy even during daytime awake hours. Do not let your child do anything that could be dangerous until you see how this medicine affects them.
  • Certain medicines can interact with melatonin. Tell your doctor and pharmacist about all medicines and supplements your child takes.
  • It is important that patients tell the care team if they are pregnant or breastfeeding. 

Melatonin at home

  • Tablet/capsule: Take at bedtime and at least 2 hours after a meal. Tablet may be crushed and mixed with water. Do not crush, chew, or break extended release or coated tablets. Swallow capsules whole.
  • Liquid suspension: Use the measuring device that comes with the medicine.
  • Do not use the medicine past the expiration date. 
  • Some medicines may need to be protected from light. Follow instructions from the pharmacy.

Learn more about melatonin

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Always check the medication label. Many medicines look the same. Do not take any new medicine, including over-the counter medicines or supplements, without checking with your doctor or pharmacist. Talk to your doctor or pharmacist about what to do in the case of a missed dose, allergic reaction, or medical emergency. 

This information is not intended to be a complete guide and is not a substitute for talking with your provider. Medicine names, appearance, formulas, or availability may vary by clinic location. Always follow the instructions given by your care team.

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Reviewed: June 2025