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Megestrol acetate

Supportive Care

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What is megestrol acetate?

Megestrol acetate (also called Megace®) is a hormone that is known to increase appetite. Megestrol is used to help patients feel hungry and to increase their food intake and weight. It is available as a white liquid suspension and as light-blue 20-mg and 40-mg tablets.

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Possible side effects

  • Nausea and vomiting
  • Diarrhea

Symptoms of an allergic reaction include: rash, hives, itching, chills, fever, headache, muscle ache, shortness of breath, coughing, tightness in the throat, swelling of the face or neck.

Not all patients who take megestrol acetate will experience these side effects. Common side effects are bolded, but there may be others. Please report all suspected side effects to your doctor or pharmacist.

Find more information on side effects.

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Possible late effects

  • Water weight gain mainly in the face, ankles, and hands
  • Increased blood sugar levels
  • Stomach upset
  • Blood clots
  • Rash
  • Headache
  • Temporary changes in liver function
  • High blood pressure
  • Need to urinate more often than usual
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Tips for patients and families

Be sure to discuss all questions and instructions with your doctor or pharmacist. 

  • Do not stop taking this medicine until your doctor tells you to do so. If you have taken this medicine for more than a year, you should slowly decrease the dose over a period of 2 to 3 weeks before you stop taking it. When decreasing the dose, if you have a fast onset of nausea and vomiting or feel dizzy or weak, tell your doctor right away.
  • You should see a dietician often to check your weight and food intake while you are taking this medicine. You will need to write down your food intake and bring the written record to your dietitian. Your dietitian will tell you how many days to write down your food intake and when you can stop keeping track of it.
  • Urine and blood tests may be needed to check for high blood sugar levels.
  • If your weight increases very fast or your appetite is too great, please call your doctor so the dose of megestrol acetate can be reduced.
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Always check the medication label. Many medicines look the same. Do not take any new medicine, including over-the counter medicines or supplements, without checking with your doctor or pharmacist. Talk to your doctor or pharmacist about what to do in the case of a missed dose, allergic reaction, or medical emergency. 

This information is not intended to be a complete guide and is not a substitute for talking with your provider. Medicine names, appearance, formulas, or availability may vary by clinic location. Always follow the instructions given by your care team.

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Reviewed: June 2024