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Linezolid

Antibiotic

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What is linezolid?

Linezolid (also called Zyvox®) is used to treat infections. It is available as a 600 mg tablet and as an orange-flavored liquid suspension. Both are taken by mouth. It is also available as a clear liquid given by vein (IV).

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Possible side effects

  • Nausea and vomiting
  • Diarrhea

Symptoms of an allergic reaction include: rash, hives, itching, chills, fever, headache, muscle ache, shortness of breath, coughing, tightness in the throat, swelling of the face or neck.

Not all patients who take linezolid will experience these side effects. Common side effects are bolded, but there may be others. Please report all suspected side effects to your doctor or pharmacist.

Find more information on side effects.

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Possible late effects

  • Anemia, low white blood cell count, low platelet count
  • Headache
  • Rash
  • Increase in blood pressure
  • Changes in liver function
  • Tingling or numbness in hands or feet

These are the most common side effects, but there may be others. Please report all side effects to the doctor or nurse.

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Tips for patients and families

Be sure to discuss all questions and instructions with your doctor or pharmacist. 

  • Follow diet instructions closely. Avoid eating or drinking large amounts of foods containing tyramine. Certain foods and drinks taken with this medicine can cause very dangerous reactions such as sudden high blood pressure. These include:
    • Aged cheeses
    • Aged, smoked, pickled, or processed meats and fish
    • Alcohol (beer, wine, liqueur)
    • Fruits, including avocados, bananas, figs, raisins
    • Soy sauce
    • Miso soup
    • Yeast/protein extracts
    • Bean curd
    • Fava or broad bean pods
    • Over ripe fruit
    • Sauerkraut
    • Caffeine (tea, coffee, chocolate, cola)
  • Linezolid may interact with other medicines. These include:
    • Amitriptyline (and other medicines known as tricyclic antidepressants)
    • Venlafaxine
    • Trazadone
    • Meperidine
    • Dextromethorphan
    • Medicines used to treat depression known as SSRIs.
  • Always give a complete list of medicines you are taking to your doctor or pharmacist. Check with your doctor or pharmacist before starting any new vitamins, herbals, or other medicines.
  • Linezolid tablets should be stored at room temperature. The oral suspension should be stored at room temperature and discarded after 21 days.
  • Keep this and all medicine out of the reach of children and pets.
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Always check the medication label. Many medicines look the same. Do not take any new medicine, including over-the counter medicines or supplements, without checking with your doctor or pharmacist. Talk to your doctor or pharmacist about what to do in the case of a missed dose, allergic reaction, or medical emergency. 

This information is not intended to be a complete guide and is not a substitute for talking with your provider. Medicine names, appearance, formulas, or availability may vary by clinic location. Always follow the instructions given by your care team.

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Reviewed: June 2024