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Fluconazole

Antifungal

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What is fluconazole?

Fluconazole (also called Diflucan®) is used to treat fungal infections. It is available as a 100-mg, 150-mg, and 200-mg pink tablet, and as a white orange-flavored liquid suspension taken by mouth. It is also available as a clear liquid given by vein.

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Possible side effects

  • Nausea and vomiting
  • Stomach upset

Symptoms of an allergic reaction include: rash, hives, itching, chills, fever, headache, muscle ache, shortness of breath, coughing, tightness in the throat, swelling of the face or neck.

Not all patients who take fluconazole will experience these side effects. Common side effects are bolded, but there may be others. Please report all suspected side effects to your doctor or pharmacist.

Find more information on side effects.

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Possible late effects

  • Diarrhea
  • Temporary changes in liver function
  • Feeling dizzy
  • Rash
  • Headache
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Tips for patients and families

Be sure to discuss all questions and instructions with your doctor or pharmacist. 

  • When taking the liquid suspension by mouth:
    • Shake the liquid suspension well before each dose.
    • Store the liquid at room temperature. Do not refrigerate.
    • Discard the liquid suspension after 14 days.
  • Fluconazole may affect the way other medicines work. These medicines include:
    • Oral medicines for diabetes,
    • Warfarin,
    • Phenytoin,
    • Cyclosporine,
    • Theophylline,
    • Zidovudine, and
    • These chemotherapy medicines:
      • Vincristine,
      • Etoposide,
      • Daunorubicin,
      • Doxorubicin,
      • Idarubicin,
      • Mitoxantrone,
      • Ifosfamide, and
      • Cyclophosphamide.
  • Several medicines can affect how fluconazole works. These medicines include:
    • hydrochlorothiazide,
    • rifampin, and
    • cimetidine.
  • Always tell your doctor if you are taking these medicines, or if you start taking any new medicine while you are taking fluconazole.
  • Take fluconazole with food if stomach upset occurs.
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Always check the medication label. Many medicines look the same. Do not take any new medicine, including over-the counter medicines or supplements, without checking with your doctor or pharmacist. Talk to your doctor or pharmacist about what to do in the case of a missed dose, allergic reaction, or medical emergency. 

This information is not intended to be a complete guide and is not a substitute for talking with your provider. Medicine names, appearance, formulas, or availability may vary by clinic location. Always follow the instructions given by your care team.

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Reviewed: June 2024