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Famotidine

Supportive Care

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What is famotidine?

Famotidine (also called Pepcid) blocks the release of stomach acid. It is used to treat stomach ulcers. It is also used to relieve pain and discomfort caused by gastroesophageal reflux disease (also called GERD or acid reflux). Famotidine is available in these forms:

  • 10-mg, 20-mg, and 40-mg tablets taken by mouth
  • 40 mg/5 mL suspension taken by mouth
  • Clear liquid given by vein (IV)
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Possible side effects

  • Headache
  • Nausea and vomiting
  • Diarrhea
  • Rash
  • Feeling dizzy
  • Feeling drowsy

    • These are the most common side effects, but there may be others. Please report all side effects to the doctor or nurse.

 

Symptoms of an allergic reaction include: rash, hives, itching, chills, fever, headache, muscle ache, shortness of breath, coughing, tightness in the throat, swelling of the face or neck.

Not all patients who take famotidine will experience these side effects. Common side effects are bolded, but there may be others. Please report all suspected side effects to your doctor or pharmacist.

Find more information on side effects.

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Tips for patients and families

Be sure to discuss all questions and instructions with your doctor or pharmacist. 

  • You may receive this drug when you are taking a steroid medicine called dexamethasone or prednisone. Steroids can sometimes irritate the stomach, and famotidine may protect your stomach.
  • Store the liquid medicine and the tablets at room temperature.
  • Shake the liquid medicine well before use. Measure the liquid doses carefully using the oral syringe that comes with this drug. Discard the liquid medicine on the expiration date written on the label.
  • You may receive this drug to mix into your TPN. Your home infusion nurse will teach you how to do this. Make sure to add famotidine to the TPN on the day of use.  Refer to How to Withdraw Medicine from a Vial.
  • Famotidine may affect the way other medicines work. These medicines include ketoconazole, dasatinib, erlotinib, pazopanib, risedronate, and cefuroxime. Always tell your doctor if you start any new medicines while taking famotidine.
  • You can buy medicines similar to famotidine without a prescription. Do not take over-the-counter medicines without telling your doctor or pharmacist.
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Always check the medication label. Many medicines look the same. Do not take any new medicine, including over-the counter medicines or supplements, without checking with your doctor or pharmacist. Talk to your doctor or pharmacist about what to do in the case of a missed dose, allergic reaction, or medical emergency. 

This information is not intended to be a complete guide and is not a substitute for talking with your provider. Medicine names, appearance, formulas, or availability may vary by clinic location. Always follow the instructions given by your care team.

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Reviewed: June 2024