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Factor VIII (Human) and von Willebrand Factor

Supportive Care

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What is Factor VIII (Human) and von Willebrand Factor?

Human Factor VIII with von Willebrand factor (also called Humate-P®) is used to help manage bleeding disorders. It is available as a clear liquid given by vein (IV).

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Possible side effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Fever or chills
  • Feeling light-headed or fainting
  • Skin or whites of eyes look yellow
  • Feeling drowsy or tired
  • Headache
  • Nausea or mild stomach pain
  • Pain, itching, swelling, burning, or a lump under your skin where the needle was placed
  • These are the most common side effects, but there may be others. Please report all side effects to your doctor or nurse.

Symptoms of an allergic reaction include: rash, hives, itching, chills, fever, headache, muscle ache, shortness of breath, coughing, tightness in the throat, swelling of the face or neck.

Not all patients who take Factor VIII (Human) and von Willebrand Factor will experience these side effects. Common side effects are bolded, but there may be others. Please report all suspected side effects to your doctor or pharmacist.

Find more information on side effects.

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Tips for patients and families

Be sure to discuss all questions and instructions with your doctor or pharmacist. 

  • Store this medicine in the refrigerator. Do not freeze it. It also may be stored at room temperature for up to 6 months. Be sure to write the date the product was placed at room temperature in the space provided on the outer carton.
  • Do not use this medicine after the expiration date.
  • You may be taught how to give your medicine at home. Make sure you understand all the instructions before giving yourself an injection.
  • Try not to miss a dose. If possible, have other family members trained to give your treatment in case you cannot give it to yourself. If you do miss a dose, ask your doctor or other health caregiver for instructions.
  • This medicine is a powder that must be mixed with a sterile water before you use it. The sterile water should come in the same package as the medicine. Let both the powdered medicine and the sterile water warm to room temperature before you mix them together.
  • If you cannot use the medicine right after you mix it, you can store it at room temperature or in the refrigerator. You must use the medicine within 3 hours of mixing.
  • Use a new needle and syringe each time you inject your medicine.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of leftover medicine, containers, and other supplies. You also need to throw away old medicine after the expiration date has passed.
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Always check the medication label. Many medicines look the same. Do not take any new medicine, including over-the counter medicines or supplements, without checking with your doctor or pharmacist. Talk to your doctor or pharmacist about what to do in the case of a missed dose, allergic reaction, or medical emergency. 

This information is not intended to be a complete guide and is not a substitute for talking with your provider. Medicine names, appearance, formulas, or availability may vary by clinic location. Always follow the instructions given by your care team.

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Reviewed: June 2024