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Moisture Barrier Creams for Diaper Dermatitis (Diaper Rash)

It is important to use an approved moisture barrier product if your child wears diapers or pull-ups or if they have skin breakdown or dermatitis in the diaper area. 

Approved products for preventing or treating diaper rash

Use these products for any patient in diapers or pull-ups, or patients who have diaper rash or skin breakdown in the diaper area. These products work best when you apply 1 of these creams at every diaper change.

EPC (Extra Protective Cream)

EPC (Extra Protective Cream)

  • Good choice of zinc oxide moisture barrier cream
  • This cream may be used if your child has urine pH testing during methotrexate infusion.
Calmoseptine

Calmoseptine

  • Good choice of zinc oxide moisture barrier cream
  • Do not use this cream if your child has urine pH testing during methotrexate infusion.
Critic-Aid Antifungal Cream

Critic-Aid Antifungal Cream

  • Use for patients with fungal rash
  • Especially used for urine incontinence
  • Do not use this cream if your child has urine pH testing during methotrexate infusion.

Products that are not approved for preventing or treating diaper rash

Do not use these products in the diaper area if your child wears diapers or pull-ups or if they have skin breakdown in the diaper area:

  • A&D Ointment
  • Butt Balm
  • Cavilon
  • Maalox
  • Silvadene
  • Aquaphor
  • Nystatin Cream
  • Steroid Creams

These ointments and creams are not moisture barriers. They hold moisture instead of protecting against it and may have ingredients that cause irritation. They can make your child’s diaper rash worse.

How to apply a moisture barrier cream

  • Use a soft cloth to clean the diaper area with warm water and mild soap and pat dry. Do not use baby wipes to clean.
  • You do not need to remove all the existing moisture barrier cream. 
  • Apply a thick layer of cream to the entire affected area.
  • You have applied enough cream when you can no longer see any skin through the cream.

Apply moisture barrier cream after each diaper change. Reapply as needed to keep the affected area covered.   

If your child gets chemotherapy medicines, wear gloves and other personal protective equipment (PPE) for diaper changes as instructed. Always follow instructions for safe handling of body fluids after chemotherapy.

Let your care team know if your child’s diaper rash gets worse or does not improve. Find more information on diaper rash (diaper dermatitis).


Reviewed: October 2025

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