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Platelet storage pool deficiencies are bleeding disorders caused by problems with platelet granules.
Granules are little sacs inside the platelet where proteins and other chemicals are stored.
Platelets are used by our bodies to create something like an internal bandage to stop bleeding. This is called a platelet plug. During the process of making a platelet plug, the platelets change shape.
Chemicals inside the granules are pushed out into the bloodstream. These chemicals signal other platelets to come and help. The chemicals allow the platelets to stick together. They also stick to the blood vessel to repair it and hold the platelet plug in place.
If this does not happen, a good platelet plug cannot form. The body could bleed too much.
The chemicals inside the granules also cause injured blood vessels to constrict (tighten) to help stop bleeding.
There are two types of granules:
The most common deficiencies are caused when platelets fail to empty the contents of the granules into the bloodstream. But some storage pool deficiencies are caused by a lack of granules.
Symptoms of storage pool deficiencies vary from one person to the next. But they are usually mild to moderate.
People with storage pool deficiencies may have the following:
The diagnosis of storage pool deficiencies requires a careful medical history. It also requires a series of tests.
In people with storage pool deficiencies:
Most people with storage pool deficiencies only need treatment during surgical procedures (including dental work) and after an injury.
Platelet storage pool deficiencies may be treated with the following:
People with inherited platelet disorders should not take:
These drugs can make bleeding symptoms worse.
Reviewed: August 2022