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Methylprednisolone

Supportive Care

Brand names:

Depo-Medrol®, Medrol®, Solu-Medrol®

Other names:

Methylprednisolone Acetate, Methylprednisolone Sodium Succinate, Methylpred

Often used for:

Inflammation, allergies, leukemia, lymphoma, side effects of cancer treatments, prevention of graft-versus-host disease (GVHD) after stem cell transplant

What is methylprednisolone?

Methylprednisolone is a type of medicine called a corticosteroid. It can be used as for many conditions. Methylprednisolone may be used to treat:

Inflammation (swelling, heat, redness, and pain)
Skin rashes
Allergies and asthma
Graft-versus-host disease (GVHD) after stem cell transplant
Certain types of cancer
Conditions of the immune system such as immune thrombocytopenia (ITP)

May be taken as a tablet by mouth

May be given into a vein by IV

May be given as a liquid injected into a muscle or joint

Possible side effects

Problems sleeping
Increased appetite
Changes in personality or mood
Stomach irritation
Heartburn
Nausea or vomiting
Weight gain
Increased blood sugar levels

Increased risk of infection
Slow wound healing
Water retention, swelling of the legs or feet
Restlessness
Fatigue or weakness
Headache

Dizziness
Acne or dry skin
Increased sweating
Eye problems
Change in the normal menstrual cycle
Increased blood pressure

Steroids have many side effects that sometimes require close monitoring (for example, by blood or urine tests) especially the longer a patient is taking them.

Not all patients who take methylprednisolone will experience these side effects. Common side effects are in bold, but there may be others. Please report all suspected side effects to your doctor or pharmacist. Find more information on side effects.

Possible long-term or late effects

Some patients may have long-term or late effects of treatment that may continue or develop months or years after treatment ends. Possible side effects of methylprednisolone with long-term use include:

Decreased muscle mass and muscle weakness
Impaired growth
Thin, fragile skin
Weak bones, osteoporosis
Eye problems including cataracts or glaucoma
Second cancers (Kaposi sarcoma)

Tips for patients and families

Be sure to discuss these and other recommendations with your care provider or pharmacist.

This medicine can weaken the immune system and increase the risk of infection. Wash hands often, keep patient areas clean, and avoid contact with people who are sick.
Your care team may suggest a low-sodium, low-sugar, high-protein diet. A clinical dietitian can suggest ways to make healthy food choices and manage increased appetite.
Sexually active patients should take steps to prevent pregnancy during treatment. Learn more about sexual health during treatment.
Patients should tell their care provider if they are pregnant or breastfeeding.

Methylprednisolone at home:

Finish all doses of the medicine as instructed by a doctor or pharmacist. Do not give more often or in greater amounts than recommended.
Take methylprednisolone at the same time each day. Take in the morning if once per day.
Take with food or milk to decrease stomach problems.
Store methylprednisolone at room temperature.
Give a missed dose as soon as possible. If it is near the time for the next dose, skip the dose. Do not give 2 doses at the same time.
Do not use the medicine past the expiration date.
Follow instructions for safe handling and disposal.

Learn more about methylprednisolone

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Always check the medication label. Many medicines look the same. Do not take any new medicine, including over-the counter medicines or supplements, without checking with your doctor or pharmacist. Talk to your doctor or pharmacist about what to do in the case of a missed dose, allergic reaction, or medical emergency.

This information is not intended to be a complete guide and is not a substitute for talking with your provider. Medicine names, appearance, formulas, or availability may vary by clinic location. Always follow the instructions given by your care team.

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Reviewed: April 2024