Imatinib

Targeted Therapy

Brand names:

Gleevec®

Other names:

Glivec, Imatinib Mesylate; STI-571

Often used for:

Leukemia

What is Imatinib?

Imatinib is a type of medicine called a targeted therapy. This medicine is a tyrosine kinase inhibitor. It acts to block certain cell signals to help keep cells from growing. Imatinib is used to treat certain Philadelphia chromosome positive leukemias including Ph+ ALL and Ph+ CML.

Patients will have regular blood draws to check blood counts and monitor liver and kidney function.

May be taken as a tablet by mouth

Possible Side Effects

Edema (swelling)
Nausea and vomiting
Muscle cramps
Musculoskeletal pain
Diarrhea
Rash
Fatigue
Abdominal pain
Hair loss
Low blood counts (may cause increased risk of infection, bleeding, anemia and/or fatigue)
Dry skin, itching
Fever
Headache
Weakness
Loss of appetite
Constipation
Vision changes, blurry vision
Back pain

Nose and throat irritation
Mouth sores
Heartburn, gas
Changes in taste
Dizziness
Night sweats
Problems sleeping
Anxiety
Infertility
Liver problems
Kidney problems
Heart problems
Bleeding
Tumor lysis syndrome
Delayed growth

Not all patients who take imatinib will experience these side effects. Common side effects are in bold, but there may be others. Please report all suspected side effects to your doctor or pharmacist.

Tips for Families

Be sure to discuss these and other recommendations with your doctor or pharmacist.

The care team may recommend medicines and/or foods to help manage diarrhea. Anti-nausea medicines may also be prescribed.
While taking this medicine, do not eat grapefruit or Seville (bitter) oranges or drink juice or beverages containing grapefruit or Seville orange.
This medicine may affect growth in children and teens. Your doctor will monitor height and weight.
Sexually active patients should take steps to prevent pregnancy during treatment and for 2 weeks after completion of therapy.
Patients should tell their doctor if they are pregnant or breastfeeding.
Tell your doctor if you start taking any new medicine while taking imatinib because this may change the blood level of imatinib or increase the side effects.
Caregivers should follow instructions for safe handling and disposal of the medicine.

Imatinib at Home:

This medicine may make you dizzy or drowsy or cause vision changes. Do not drive or do anything that could be dangerous until you see how this medicine affects you.
Take imatinib with a meal at the same time each day. Take with a full glass of water.
Swallow tablets whole. Do not crush or chew.
The tablet may be dissolved in water or apple juice. Use about 50 mL of liquid for the 100 mg tablet or about 200 mL for 400 mg tablet. Mix in a glass, and stir well. Take the medicine right away. To make sure all the medicine is taken, add a little juice to the glass, swish it around, and drink. Never take imatinib with grapefruit juice.
Your pharmacist may prepare a liquid form of imatinib for you. Follow the dosing instructions provided.
Caregivers should wear gloves when handling this medicine. If the medicine gets on your skin, wash the area right away.
Store the medicine at room temperature.
In case of a missed dose, skip the dose. Do not give 2 doses at the same time.
Do not use the medicine past the expiration date.
Follow instructions for safe handling and disposal.

Imatinib resources

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Always check the medication label. Many medicines look the same. Do not take any new medicine, including over-the counter medicines or supplements, without checking with your doctor or pharmacist. Talk to your doctor or pharmacist about what to do in the case of a missed dose, allergic reaction, or medical emergency.

This information is not intended to be a complete guide and is not a substitute for talking with your provider. Medicine names, appearance, formulas, or availability may vary by clinic location. Always follow the instructions given by your care team.