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Zidovudine / Lamivudine (Combivir®)

Antiretroviral

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What is Zidovudine / Lamivudine (Combivir®)?

Combivir® is a tablet that contains 2 medicines used to treat infection caused by the human immunodeficiency virus (HIV). The 2 medicines are called zidovudine (Retrovir®, ZDV, or AZT) and lamivudine (Epivir® or 3TC). Both medicines belong to a group called nucleoside reverse transcriptase inhibitors (NRTIs). Combivir® can slow down how soon you will see symptoms or slow the damage caused by HIV, but it cannot cure HIV infection. Combivir® tablets contain 300 mg of zidovudine and 150 mg of lamivudine.

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Possible side effects

  • Headache
  • Unusual tired feeling
  • Low blood counts
  • Nausea
  • Vomiting
  • Diarrhea
  • Loss of appetite
  • These are the most common side effects, but there may be others. Please report all side effects to the doctor or nurse.

Symptoms of an allergic reaction include: rash, hives, itching, chills, fever, headache, muscle ache, shortness of breath, coughing, tightness in the throat, swelling of the face or neck.

Not all patients who take Combivir® will experience these side effects. Common side effects are bolded, but there may be others. Please report all suspected side effects to your doctor or pharmacist.

Find more information on side effects.

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Tips for patients and families

Be sure to discuss all questions and instructions with your doctor or pharmacist. 

  • Combivir® tablets can be stored at room temperature.
  • Blood tests can find some side effects, such as low blood counts. It is very important that you come to the clinic regularly for blood tests.

Drug at Home:

  • This medicine is usually taken one (1) time in the morning and one (1) time at night.
  • Take Combivir® with or without food. Taking this medicine right after you have eaten a meal may help prevent upset stomach.
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Always check the medication label. Many medicines look the same. Do not take any new medicine, including over-the counter medicines or supplements, without checking with your doctor or pharmacist. Talk to your doctor or pharmacist about what to do in the case of a missed dose, allergic reaction, or medical emergency. 

This information is not intended to be a complete guide and is not a substitute for talking with your provider. Medicine names, appearance, formulas, or availability may vary by clinic location. Always follow the instructions given by your care team.

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