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Desmopressin (Stimate®)

Supportive Care

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What is desmopressin?

Desmopressin (also called Stimate®) is used to help manage bleeding disorders. It is available as spray that is squirted in the nose.

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Possible side effects

  • Headache or dizzy feeling that does not go away
  • Runny or stuffy nose
  • Nosebleeds
  • Cough or sore throat
  • Watery eyes
  • Nausea, vomiting, or upset stomach
  • Rapid weight gain
  • Swelling of feet, legs, or ankles
  • Fatigue and muscle weakness
  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

    These are the most common side effects, but there may be others. Please report all side effects to your doctor or nurse.

Symptoms of an allergic reaction include: rash, hives, itching, chills, fever, headache, muscle ache, shortness of breath, coughing, tightness in the throat, swelling of the face or neck.

Not all patients who take desmopressin will experience these side effects. Common side effects are bolded, but there may be others. Please report all suspected side effects to your doctor or pharmacist.

Find more information on side effects.

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Tips for patients and families

Be sure to discuss all questions and instructions with your doctor or pharmacist. 

  • If you are using the nasal spray for the first time, you need to pump or squeeze the bottle until some of the medicine sprays out. Always prime the spray if you have not used the medicine for 5 days or longer.
  • Before using the medicine, gently blow your nose to clear the nostrils. After using this medicine, wipe the tip of the bottle with a clean tissue then replace the cap.
  • On the days that you use this medicine, only drink enough fluids to quench thirst.
  • Do not use this medicine for more than 3 days in a row. If the bleeding has not stopped after 3 days, please notify your clinic.
  • Store this medicine in the refrigerator. Do not freeze it. For travelers, desmopressin is good for 3 weeks at room temperature.
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Always check the medication label. Many medicines look the same. Do not take any new medicine, including over-the counter medicines or supplements, without checking with your doctor or pharmacist. Talk to your doctor or pharmacist about what to do in the case of a missed dose, allergic reaction, or medical emergency. 

This information is not intended to be a complete guide and is not a substitute for talking with your provider. Medicine names, appearance, formulas, or availability may vary by clinic location. Always follow the instructions given by your care team.

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