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Atazanavir (Reyataz®)

Antiretroviral

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What is atazanavir?

Atazanavir (Reyataz®) is a capsule that contains medicine used to treat infection caused by the human immunodeficiency virus (HIV). Atazanavir belongs to a group of medicines known as protease inhibitors (PIs). Atazanavir can slow down how soon you will see symptoms of HIV or slow the damage caused by HIV, but it cannot cure HIV infection. Atazanavir is available as a 100 mg, 150 mg, 200 mg, and 300 mg capsule.

Laboratory testing

Atazanavir has the ability to block an enzyme in the body called UGT1A1. UGT1A1 is responsible for removing bilirubin from your body. Bilirubin is made in the body when your red blood cells break down through a natural process. If bilirubin is not removed from your body, your skin and eyes can turn yellow. The medical word for this is “jaundice.” A genetic test can be done to determine how well your UGT1A1 works. If your UGT1A1 works slowly, you should avoid atazanavir because you may become jaundiced. Certain people whose UGT1A1 works slowly may have a condition called Gilbert syndrome. For information about UGT1A1 and how it is affected by atazanavir, talk with your doctor or pharmacist, and see “Do you know… UGT1A1 and medicines.” For more details, go to stjude.org/pg4kds.

How to take atazanavir

  • This tablet is usually taken one (1) time each day.
  • Atazanavir should be taken with food.
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Possible side effects

  • Rash
  • Feeling more tired than usual
  • Low blood counts
  • Headache
  • Nausea
  • High blood cholesterol levels
  • High blood glucose levels
  • Increased liver function tests
  • Yellowing of the whites of the eyes

Symptoms of an allergic reaction include: rash, hives, itching, chills, fever, headache, muscle ache, shortness of breath, coughing, tightness in the throat, swelling of the face or neck.

Not all patients who take atazanavir will experience these side effects. Common side effects are bolded, but there may be others. Please report all suspected side effects to your doctor or pharmacist.

Find more information on side effects.

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Tips for patients and families

Be sure to discuss all questions and instructions with your doctor or pharmacist. 

  • Atazanavir capsules should be stored at room temperature and away from heat and moisture.
  • Some side effects, such as low blood counts, can be found with blood tests. So it is very important that you come to clinic at regularly planned times and have blood tests done.
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Always check the medication label. Many medicines look the same. Do not take any new medicine, including over-the counter medicines or supplements, without checking with your doctor or pharmacist. Talk to your doctor or pharmacist about what to do in the case of a missed dose, allergic reaction, or medical emergency. 

This information is not intended to be a complete guide and is not a substitute for talking with your provider. Medicine names, appearance, formulas, or availability may vary by clinic location. Always follow the instructions given by your care team.

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