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Alkaline Saline Mouthrinse Solution

What is an alkaline saline mouthrinse?

An alkaline saline mouthrinse is a rinse you can make at home to help manage mouth and throat sores. Some treatments, such as chemotherapy or radiation, may affect the cells in the mouth and digestive tract and cause mucositis. This may cause redness, swelling, tenderness, and sores on the lining of the mouth, tongue, and lips.

Benefits of an alkaline saline mouthrinse

An alkaline saline mouthrinse can:

  • Help reduce mouth acid and irritation  
  • Keep your child’s mouth clean and moist
  • Help promote healing and prevent infection 
  • Make eating, drinking, and talking more comfortable

You can make this rinse at home using simple ingredients. 

How to make an alkaline saline mouthrinse

Supplies needed

  • 4 cups of warm water
  • 1 teaspoon of table salt
  • 1 teaspoon of baking soda (sodium bicarbonate)
  • Container with a lid or cap that can hold 4 cups of liquid

How to make the solution

  1. Measure 4 cups of warm water into a container. 
  2. Add 1 teaspoon of table salt to the water.
  3. Add 1 teaspoon of baking soda (sodium bicarbonate) to the water.
  4. Stir or shake the solution until dissolved. It should look clear. 
  5. Store the solution in a container with a lid for up to 14 days.

The solution can be stored at room temperature. After 14 days, pour it down the sink to discard. 

How to use the mouthrinse 

  • Measure 15 milliliters (mL) or about 1 tablespoon of solution.
  • Swish in the mouth and gargle for 15 to 30 seconds.
  • Spit the solution out. Do not swallow the mouthrinse.
  • Use the mouthrinse every 4-6 hours or as instructed by your care team.

Key points about an alkaline saline mouthrinse

  • An alkaline saline mouthrinse can help treat oral mucositis and mouth sores.
  • You can make an alkaline saline solution at home using simple ingredients.
  • Have your child use the mouthrinse every 4-6 hours.
  • Always follow your care team’s instructions for mouth care.


Reviewed: July 2025

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