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Often used for:
Treatment of cytokine release syndrome (CRS)
Siltuximab is used to treat severe cytokine release syndrome (CRS) during CAR T-cell immunotherapy. This drug blocks a protein called interleukin-6 (IL-6) and acts to decrease the body’s immune response (immunosuppressant) and lower cytokine production.
Patients will have regular blood draws to check blood counts and monitor kidney and liver function. Blood pressure, heart rate, breathing, and temperature may be monitored to watch for infusion-related side effects.
This drug may increase the risk of infection, especially in patients with a weak immune system.
May be given as a liquid into a vein by IV
Not all patients who take siltuximab will experience these side effects. Common side effects are bolded, but there may be others. Please report all suspected side effects to your doctor or pharmacist.
Be sure to discuss these and other recommendations with your doctor or pharmacist.
Also see: Tisagenlecleucel