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Rilpivirine / emtricitabine / tenofovir (Complera®)

Supportive Care

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What is Complera®?

Complera® is a tablet that contains 3 medicines used to treat infection caused by the human immunodeficiency virus (HIV). The 3 medications are called rilpivirine (Edurant®), emtricitabine (Emtriva®), and tenofovir (Viread®). Rilpivirine belongs to a group of medicines known as nonnucleoside reverse transcriptase inhibitors (NNRTIs). Emtricitabine and tenofovir belong to a group called nucleoside reverse transcriptase inhibitors (NRTIs). Complera® can slow down how soon you will see symptoms of HIV or slow the damage caused by HIV, but it cannot cure HIV infection. Complera® tablets contain 25 mg of rilpivirine, 200 mg emtricitabine, and 300 mg tenofovir.

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Possible side effects

  • Rash
  • Feeling more tired than usual
  • Low blood counts
  • Headache
  • Nausea
  • Vomiting
  • Feeling drowsy

    These are the most common side effects, but there may be others. Please report all side effects to the doctor or nurse.

Symptoms of an allergic reaction include: rash, hives, itching, chills, fever, headache, muscle ache, shortness of breath, coughing, tightness in the throat, swelling of the face or neck.

Not all patients who take Complera® will experience these side effects. Common side effects are bolded, but there may be others. Please report all suspected side effects to your doctor or pharmacist.

Find more information on side effects.

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Tips for patients and families

Be sure to discuss all questions and instructions with your doctor or pharmacist. 

  • Complera® tablets should be stored at room temperature and away from heat and moisture.
  • Take Complera® with a high fat meal.
  • Some side effects, such as low blood counts, can be found with blood tests. So, it is very important that you come to clinic at regularly planned times and have blood tests done.

Drug at Home:

  • This tablet is usually taken one (1) time each day.
  • Complera® should be taken with a high fat meal.
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Always check the medication label. Many medicines look the same. Do not take any new medicine, including over-the counter medicines or supplements, without checking with your doctor or pharmacist. Talk to your doctor or pharmacist about what to do in the case of a missed dose, allergic reaction, or medical emergency. 

This information is not intended to be a complete guide and is not a substitute for talking with your provider. Medicine names, appearance, formulas, or availability may vary by clinic location. Always follow the instructions given by your care team.

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