Fluoxetine

Antidepressant

Brand names:

Prozac®

Other names:

Fluoxetine hydrochloride

Often used for:

Depression, Anxiety, Obsessive-compulsive disorder (OCD), Eating disorders, Premenstrual dysphoric disorder (PMDD), Post-traumatic stress disorder (PTSD), Fibromyalgia.

What is fluoxetine?

Fluoxetine (Prozac®) is a type of antidepressant medication called a selective serotonin reuptake inhibitor (SSRI). It is used to treat mental health conditions, such as depression and anxiety.

Fluoxetine works by increasing the amount of serotonin in the brain. Serotonin is a natural substance in the brain that may help regulate mood.

This medicine may be given in the clinic, hospital, or at home. It may be used along with other medicines.

May be given as a tablet by mouth

May be given as a capsule by mouth

May be given as a liquid by mouth

Possible side effects

Feeling tired or weak
Sleep problems (trouble sleeping)
Nausea
Diarrhea
Loss of appetite
Dry mouth
Tremors (shaking of the body)
Uncontrolled yawning
Headache
Sexual dysfunction/fertility issues

Not all patients who take fluoxetine will have these side effects. Common side effects are in bold, but there may be others. Report any symptoms or side effects to your doctor or pharmacist.

Find more information on side effects.

Tips for patients and families

Be sure to discuss all questions and instructions with your health care provider or pharmacist.

It may take several weeks to see the full effects of this medicine. Contact your health care provider or pharmacist if symptoms get worse or do not improve. 
Watch for changes in your child’s mood or mental health, such as worsening depression, anxiety, agitation, irritability, panic attacks, and trouble sleeping. 
Seek medical help right away if your child has any suicidal thoughts or actions or signs of self-harm. 
Do not stop taking this medicine without talking to a health care provider. 
This medicine may make your child drowsy. Do not let your child do anything that could be dangerous until you see how this medicine affects them.
Your child may bleed or bruise more easily. Or experience slow wound healing, especially if taking other medications that affect bleeding. Brush teeth gently with a soft toothbrush, use an electric razor to shave, and avoid activities that can cause injury.
This medicine can increase the risk of eye problems. Let your care team know if your child has eye pain or change in eyesight. 
Fluoxetine can affect your child’s ability to get pregnant or father a child. Talk to your doctor about the risk of fertility problems.
It is important that patients tell the care team if they are sexually active, pregnant, or breastfeeding.
This medicine may affect interest in sex and the ability to have or keep an erection. Patients should discuss this with their health care team if they have questions or concerns.

Fluoxetine at home

Give this medicine in the morning at the same time every day.
This medicine can be taken with or without food. Take with food if stomach upset occurs. Taking the medicine with meals may lessen stomach problems. 
Tablets and capsules: Take as directed. Swallow tablet or capsule whole unless otherwise directed. Do not crush, chew, or break extended release or coated tablets.
Liquid: Use the measuring device that comes with the medicine. Shake well before use. Store in refrigerator.
In case of a missed dose, give the missed dose as soon as possible. If it is near the time for the next dose, skip the missed dose. Do not give 2 doses at the same time.
Do not use the medicine past the expiration date.
Follow instructions for safe handling, storage, and disposal.

Learn more about fluoxetine

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Always check the medication label. Many medicines look the same. Do not take any new medicine, including over-the counter medicines or supplements, without checking with your doctor or pharmacist. Talk to your doctor or pharmacist about what to do in the case of a missed dose, allergic reaction, or medical emergency.

This information is not intended to be a complete guide and is not a substitute for talking with your provider. Medicine names, appearance, formulas, or availability may vary by clinic location. Always follow the instructions given by your care team.

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Reviewed: July 2024