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Factor VIII (Recombinant)

Supportive Care

Brand names:


Often used for:

Hemophilia A

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What is Factor VIII?

Factor VIII (also called Advate®) is used to help manage bleeding disorders. It is available as a clear liquid given by vein (IV).

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May be given by liquid IV

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Possible side effects

  • Blurred vision
  • Dark-colored urine
  • Skin or whites of eyes look yellow
  • Headache
  • Loss of appetite
  • Nausea, vomiting, or stomach pain
  • Feeling nervous
  • Pain, itching, burning, swelling, or a lump under your skin where the needle was placed
  • Feeling tired

Symptoms of an allergic reaction include: itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.

Not all patients who take Factor VIII will experience these side effects. Common side effects are bolded, but there may be others. Please report all suspected side effects to your doctor or pharmacist.

Find more information on side effects.

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Tips for patients and families

Be sure to discuss all questions and instructions with your doctor or pharmacist. 

  • Store this medicine in the refrigerator. Do not freeze it. It also may be stored at room temperature for up to 6 months. Be sure to write the date the product was placed at room temperature in the space provided on the outer carton.
  • Do not use this medicine after the expiration date.
  • You may be taught how to give your medicine at home. Make sure you understand all the instructions before giving yourself an injection.
  • Try not to miss a dose. If possible, have other family members trained to give your treatment in case you cannot give it to yourself. If you do miss a dose, ask your doctor or other health caregiver for instructions.
  • This medicine is a powder that must be mixed with sterile water before you use it. The sterile water should come in the same package as the medicine. Let both the powdered medicine and the sterile water warm to room temperature before you mix them together.
  • If you cannot use the medicine right after you mix it, you can store it at room temperature or in the refrigerator. You must use the medicine within 3 hours of mixing.
  • Use a new needle and syringe each time you inject your medicine.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of leftover medicine, containers, and other supplies. You also need to throw away old medicine after the expiration date has passed.