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Erwinia Asparaginase

Chemotherapy

Brand names:

Rylaze®

Other names:

Asparaginase Erwinia chrysanthemi

Often used for:

Leukemia

About Erwinia asparaginase

Erwinia asparaginase is a chemotherapy. It works by slowing or stopping the growth of cells. It is used in combination with other medicines. Erwinia asparaginase is given to patients who have had reactions to similar drugs such as asparaginase (Elspar®) and/or pegaspargase (Oncaspar®).

Patients will be monitored closely for signs of an allergic reaction.

Patients will have regular blood draws to check blood counts, blood clotting factors, pancreatic enzymes, blood sugar, and monitor liver and kidney function.

May be injected into a muscle

May be given as a liquid into a vein by IV

Possible side effects

Increased blood sugar levels
Increased risk of bleeding or blood clots
Liver problems
Increased triglyceride levels in the blood
Nausea and vomiting
Fever
Ongoing abdominal pain that may spread to the back, inflammation of the pancreas (pancreatitis)
Increased risk of stroke
Swelling, pain, redness, and warmth at the injection site if given into muscle

Symptoms of an allergic reaction may include: hives, rash, itching, difficulty breathing and/or swallowing

Not all patients who take Erwinia asparaginase will experience these side effects. Common side effects are in bold, but there may be others. Please report all suspected side effects to your doctor or pharmacist.

Tips for families

Be sure to discuss these and other recommendations with your doctor or pharmacist.

Patients should tell a doctor if they:
- Have or ever had pancreatitis, blood clots, or severe bleeding, especially if these happened during treatment with asparaginase (Elspar®) or pegaspargase (Oncaspar®)
- Have or ever had diabetes
Sexually active patients should take steps to prevent pregnancy during treatment and for 6 months after completion of therapy.
Patients should tell their doctor if they are pregnant or breastfeeding.

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Always check the medication label. Many medicines look the same. Do not take any new medicine, including over-the-counter medicines or supplements, without checking with your doctor or pharmacist. Talk to your doctor or pharmacist about what to do in the case of a missed dose, allergic reaction, or medical emergency. This information is not intended to be a complete guide and is not a substitute for talking with your provider. Medicine names, appearance, formulas, or availability may vary by clinic location. Always follow the instructions given by your care team.