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Efavirenz / emtricitabine / tenofovir (Atripla®)

Antiretroviral

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What is Atripla®?

Atripla® is a tablet that contains 3 medicines used to treat infection caused by the human immunodeficiency virus (HIV). The 3 medications are called efavirenz (Sustiva®), emtricitabine (Emtriva®), and tenofovir (Viread®). Efavirenz belongs to a group of medicines known as nonnucleoside reverse transcriptase inhibitors (NNRTIs). Emtricitabine and tenofovir belong to a group called nucleoside reverse transcriptase inhibitors (NRTIs). Atripla® can slow down how soon you will see symptoms of HIV or slow the damage caused by HIV, but it cannot cure HIV infection. Atripla® tablets contain 600 mg of efavirenz, 200 mg emtricitabine, and 300 mg tenofovir.

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Possible side effects

  • Rash
  • Feeling more tired than usual
  • Low blood counts
  • Headache
  • Nausea
  • Vomiting
  • Unusual dreams
  • Feeling dizzy or drowsy
  • These are the most common side effects, but there may be others. Please report all side effects to the doctor or nurse.

Symptoms of an allergic reaction include: rash, hives, itching, chills, fever, headache, muscle ache, shortness of breath, coughing, tightness in the throat, swelling of the face or neck.

Not all patients who take Atripla® will experience these side effects. Common side effects are bolded, but there may be others. Please report all suspected side effects to your doctor or pharmacist.

Find more information on side effects.

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Tips for patients and families

Be sure to discuss all questions and instructions with your doctor or pharmacist. 

  • Atripla® tablets should be stored at room temperature and away from heat and moisture.
  • Administer Atripla® with water on an empty stomach due to possible effects of food with the medication.
  • Take Atripla® at bedtime to decrease adverse effects such as feeling dizzy and drowsy.
  • Some side effects, such as low blood counts, can be found with blood tests, So it is very important that you come to clinic at regularly planned times and have blood tests done.

Drug at Home:

  • This tablet is usually taken one (1) time each day.
  • Atripla® should be taken with water on an empty stomach.
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Always check the medication label. Many medicines look the same. Do not take any new medicine, including over-the counter medicines or supplements, without checking with your doctor or pharmacist. Talk to your doctor or pharmacist about what to do in the case of a missed dose, allergic reaction, or medical emergency. 

This information is not intended to be a complete guide and is not a substitute for talking with your provider. Medicine names, appearance, formulas, or availability may vary by clinic location. Always follow the instructions given by your care team.

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