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Brand names:


Other names:

Calaspargase pegol, Calaspargase pegol-mknl injection

Often used for:


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About calaspargase

Calaspargase (Asparlas®) is a type of chemotherapy. It works by slowing or stopping the growth of cells. It may be used in combination with other medicines to treat acute lymphoblastic leukemia (ALL). 

After the infusion, the care team will watch your child closely for signs of an allergic reaction. Your child will have regular tests to check blood counts, blood clotting factors, pancreatic enzymes, blood sugar, liver function, and kidney function.

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 Given as a liquid into a vein by IV

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Possible side effects

  • High blood sugar levels
  • Increased risk of bleeding or blood clots
  • Liver problems
  • Ongoing abdominal pain that may spread to the back, inflammation of the pancreas (pancreatitis)
  • Increased triglyceride levels in the blood
  • Fever
  • Nausea and vomiting
  • Diarrhea
  • Headache
  • Increased risk of stroke

Allergic Reaction: Symptoms of an allergic reaction may include hives, rash, itching, and difficulty breathing or swallowing.

Not all patients who take this medicine will have these side effects. Common side effects are in bold, but there may be others. Please report any symptoms or side effects to your doctor or pharmacist. Find more information on side effects.

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Tips for patients and families

Be sure to discuss all questions and instructions with your doctor or pharmacist.

  • After getting calaspargase, your child may be monitored for 1 hour for symptoms of an allergic reaction.
  • Tell your care team if your child has or has ever had:
  • Contact your health care provider if your child has severe stomach pain, back pain, or sudden abdominal (belly) pain. Also call your clinic for any bad headache, chest pain, shortness of breath, pain or swelling in a leg or arm, or problems with vision, speech, or walking.
  • Your child may bleed more easily. Brush teeth gently with a soft toothbrush and avoid activities that can cause injury.
  • If your child has unusual thirst or hunger or urinates (pees) more often than normal, tell your care team right away.
  • It is important that patients tell the care team if they are sexually active, pregnant, or breastfeeding.
  • Sexually active patients should take steps to prevent pregnancy during treatment and for 3 months after treatment is complete. Use a non-hormone form of birth control.