Mpox is an infection caused by the monkeypox virus. It can cause rash, fever, fatigue, and swollen lymph nodes. The illness is usually mild. However, people with weak immune systems are at higher risk for more severe illness.
Mpox is part of the same family of viruses that causes smallpox. The virus got its name because it was first found in monkeys. Mpox is not related to chickenpox.
The main way mpox spreads is through close contact with the rash or body fluids of someone with the virus. It can also spread from infected animals to people.
There is no specific FDA-approved treatment for mpox. The mpox vaccine can help prevent infection for people at higher risk or who have been exposed to the virus.
Signs and symptoms of mpox include:
The most common symptom of mpox is a rash, which can be painful.
Symptoms usually develop within 3 weeks (21 days) after exposure to the virus. The illness often lasts for 2–4 weeks.
Your health care provider will do a physical exam and ask about symptoms and possible exposure to the virus.
To confirm a mpox diagnosis, your health care provider will take samples from the rash to be tested in the lab. They may also do blood tests.
If you suspect you have mpox, stay home and avoid contact with others until you know your results. If the test is positive, take steps to prevent spreading the virus to others.
The infection is usually mild. Most people only need supportive care, such as medicines for pain or fever.
People at higher risk for more severe illness may be treated with antiviral medicines. People are more likely to become sick from mpox if they:
Mpox vaccines may be recommended if you:
If you have been exposed to mpox or think you might be eligible for a vaccine, talk to your health care provider.
Mpox spreads through close contact with the virus. This includes:
A person can spread mpox from the time that symptoms start until the scabs fall off, the skin has healed, and new skin has formed. To prevent the spread of mpox to others:
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Reviewed: June 2025
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