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Rho(D) Immune Globulin (WinRho® SDF)

Immune Therapy Immune Globulin

Brand names:

WinRho® SDF, HyperRHO S/D Full Dose, HypRho-D, RhoGAM

Often used for:

Treating low platelet counts, immune thrombocytopenia (ITP)

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What is WinRho® SDF?

WinRho® SDF is a type of immunotherapy medicine used to treat low platelets in people with immune thrombocytopenia (ITP). It is also called an immune globulin medicine.

Your child might get WinRho® SDF if they have:

  • ITP and bleeding symptoms
  • Very low platelet counts that put them at high risk of bleeding
  • Positive blood type (such as O+, A+, B+, or AB+)

WinRho® SDF has antibodies to the D antigen. People with Rh-positive blood, including O+, A+, B+, or AB+, have the D antigen in their blood. WinRho® SDF helps increase the number of platelets in Rh-positive blood.

This medicine may be given in a clinic or hospital.

Patients will receive other medicines called diphenhydramine (Benadryl®) and acetaminophen (Tylenol®) 30 minutes before the infusion. Your care team will order tests to check blood counts and monitor liver and kidney function. The care team may also check heart rhythm.

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Given into a vein by IV

 
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Possible side effects

Side effects usually happen 4 to 8 hours after an infusion.
  • Fever
  • Chills
  • Headache
  • Weakness
  • Lightheadedness, dizziness, or fainting

Tell your health care team right away if you have any of the following severe side effects: Sudden weight gain or swelling in the arms or legs, dark urine (pee) or blood in the urine, trouble urinating (peeing), shortness of breath, dizziness, or signs of a blood clot, including a painful lump or swelling.

Symptoms of an allergic reaction may include rash, hives, itching, fever, chills, headache, muscle ache, shortness of breath, coughing, tightness in the throat, dizziness, low blood pressure, pain in the chest, side, or back, swelling of the face or neck.

Not all patients who take WinRho® SDF will have these side effects. Common side effects are in bold, but there may be others. Please report any symptoms or side effects to your doctor or pharmacist. Find more information on side effects.

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Tips for patients and families

Be sure to discuss all questions and instructions with your doctor or pharmacist.

  • Some patients may have a reaction to this medicine. Let your care team know about any symptoms during the infusion. 
  • Tell all your child’s health care providers they are receiving this medicine. This includes your child’s dentist, pharmacist, and anyone who takes care of your child’s health.
  • Make sure your child drinks plenty of liquids.
  • Your child should not receive any vaccines for 3 months after receiving this medicine. Talk to your care team about vaccines.
  • It is important that patients tell the care team if they are sexually active, pregnant, or breastfeeding.
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Always check the medication label. Many medicines look the same. Do not take any new medicine, including over-the counter medicines or supplements, without checking with your doctor or pharmacist. Talk to your doctor or pharmacist about what to do in the case of a missed dose, allergic reaction, or medical emergency. 

This information is not intended to be a complete guide and is not a substitute for talking with your provider. Medicine names, appearance, formulas, or availability may vary by clinic location. Always follow the instructions given by your care team.

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Reviewed: January 2024