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A measurement of the energy content of food. The body needs calories as to perform its functions, such as breathing, circulating the blood, and physical activity. When a person is sick, their body may need extra calories to fight fever or other problems.
Develops when cells in your body begin to grow out of control. Normal cells grow, divide, and die naturally. Instead of dying, cancer cells continue to grow and form new abnormal cells. Cancer cells often travel to other body parts where they grow and replace normal tissue. This process is called metastasis. Cancer cells develop because of damage to DNA. DNA is in every cell and directs all its activities. When DNA becomes damaged, the body is usually able to repair it. In cancer cells, the damage is not repaired. People can inherit damaged DNA, which accounts for inherited cancers. Many times, DNA becomes damaged by exposure to something in the environment, like smoking. Many cancers have no known cause.
A condition that develops in some people who are diagnosed with cancer. Symptoms of cancer-related post-traumatic stress (PTS) include having frightening thoughts or trouble sleeping, being distracted or overexcited, feeling alone, or losing interest in daily activities. Symptoms may also include feelings of shock, fear, helplessness, or horror. Cancer-related PTS can occur anytime after diagnosis, including during or after treatment. Relaxation training, counseling, support groups, and certain medicines may be used to reduce symptoms of PTS.
Describes the smaller groups that a type of cancer can be divided into, based on certain characteristics of the cancer cells. These characteristics include how the cancer cells look under a microscope and whether there are certain substances in or on the cells or certain changes to the DNA of the cells. It is important to know the subtype of a cancer in order to plan treatment and determine prognosis.
A type of vaccine that is usually made from a patient’s own tumor cells or from substances taken from tumor cells. A cancer vaccine may help the immune system kill cancer cells. Also called cancer vaccine.
A type of vaccine that is usually made from a patient’s own tumor cells or from substances taken from tumor cells. A cancer vaccine may help the immune system kill cancer cells. Also called cancer treatment vaccine.
A condition in which Candida albicans, a type of yeast, grows out of control in moist skin areas of the body. It is usually a result of a weakened immune system, but can be a side effect of chemotherapy or treatment with antibiotics. Candidiasis usually affects the mouth (oral candidiasis); however, rarely, it spreads throughout the entire body. Also called candidosis and thrush.
Tiny blood vessels located throughout the tissues of your body which connect your arteries with your veins and through which substances pass to nourish your cells.
A type of treatment in which a patient's T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. T cells are taken from a patient’s blood. Then the gene for a special receptor that binds to a certain protein on the patient’s cancer cells is added in the laboratory. The special receptor is called a chimeric antigen receptor (CAR). Large numbers of the CAR T cells are grown in the laboratory and given to the patient by infusion. CAR T-cell therapy is being studied in the treatment of some types of cancer. Also called chimeric antigen receptor T-cell therapy.
Any substance that causes cancer.
Pertaining to your heart.
A doctor who has special training to diagnose and treat diseases of the heart and blood vessels.
Having to do with the heart and lung.
A person who gives care to people who need help taking care of themselves. Examples include children, the elderly, or patients who have chronic illnesses or are disabled. Caregivers may be health professionals, family members, friends, social workers, or members of the clergy. They may give care at home or in a hospital or other health care setting.
A study that compares two groups of people: those with the disease or condition under study (cases) and a very similar group of people who do not have the disease or condition (controls). Researchers study the medical and lifestyle histories of the people in each group to learn what factors may be associated with the disease or condition. For example, one group may have been exposed to a particular substance that the other was not. Also called retrospective study.
A registered nurse who has special training in how to plan, manage, and evaluate all aspects of patient care, especially for patients who get treatment over a long time. Also called nurse case manager.
A detailed report of the diagnosis, treatment, and follow-up of an individual patient. Case reports also contain some demographic information about the patient (for example, age, gender, ethnic origin).
A group or series of case reports involving patients who were given similar treatment. Reports of case series usually contain detailed information about the individual patients. This includes demographic information (for example, age, gender, ethnic origin) and information on diagnosis, treatment, response to treatment, and follow-up after treatment.
A type of neurohormone (a chemical that is made by nerve cells and used to send signals to other cells). Catecholamines are important in stress responses. High levels cause high blood pressure which can lead to headaches, sweating, pounding of the heart, pain in the chest, and anxiety. Examples of catecholamines include dopamine, epinephrine (adrenaline), and norepinephrine (noradrenaline).
Flexible tube used to deliver fluids into or withdraw fluids from the body.
The basic unit of which all living things are made. Cells replace themselves by splitting and forming new cells (mitosis). The processes that control the formation of new cells and the death of old cells are disrupted in cancer.
Refers to cell types or structure.
An inflammation of body tissue (especially that below the skin). It may be accompanied by fever, redness, swelling and warmth at the site.
Refers to the brain and spinal cord.
A device used to draw blood and give treatments, including intravenous fluids, drugs, or blood transfusions. A thin, flexible tube is inserted into a vein, usually below the collarbone. It is guided (threaded) into a large vein above the right side of the heart called the superior vena cava. A needle is inserted into a port outside of the body to draw blood or give fluids. A central venous access catheter may stay in place for weeks or months and helps avoid the need for repeated needle sticks. There are several types of central venous access catheters.
A condition that may occur in patients who have had surgery to remove a tumor in certain parts of the brain, including the cerebellum. Cerebellar mutism syndrome usually appears 1 or 2 days after surgery. Symptoms include loss of speech, trouble swallowing and eating, loss of balance, trouble walking, loss of muscle tone, mood swings, and changes in personality. Many of these symptoms go away over time.
The portion of the brain in the back of the head between the cerebrum and the brain stem. The cerebellum controls balance for walking and standing, and other complex motor functions.
Fluid at the brain and spine.
The fluid that flows in and around the hollow spaces of the brain and spinal cord, and between two of the meninges (the thin layers of tissue that cover and protect the brain and spinal cord). Cerebrospinal fluid is made by tissue called the choroid plexus in the ventricles (hollow spaces) in the brain. Also called CSF.
The largest part of the brain. It is divided into two hemispheres, or halves, called the cerebral hemispheres. Areas within the cerebrum control muscle functions and also control speech, thought, emotions, reading, writing, and learning.
Your written medical records.
Using chemical agents or drugs to destroy malignant cells. Chemotherapy is often used with surgery or radiation to treat cancer. Some chemotherapy treatment plans have different phases: Induction -intensive treatment used to produce a complete remission. Maintenance - drugs given after the initial "induction" to maintain the remission.
The muscles, bones, and joints that make up the area of the body between the neck and the abdomen.
A healthcare professional who is trained in the emotional and developmental needs of children. The child-life specialist helps children and their families understand medical issues and gives psychological and emotional support. Also called child-life worker.
A term used to describe cancers that occur between birth and 15 years of age. Childhood cancers are very rare and may differ from adult cancers in the way they grow and spread, how they are treated, and how they respond to treatment. Common types of childhood cancer include leukemia (begins in blood-forming tissue such as bone marrow), lymphoma (begins in the cells of the immune system), neuroblastoma (begins in certain nerve cells), retinoblastoma (begins in the tissues of the retina), Wilms tumor (a type of kidney cancer), and cancers of the brain, bone, and soft tissue.
A group of children with cancer that has been formed based on certain characteristics of the children and their disease. These may include age at diagnosis, stage of cancer, and cancer biology. Risk groups may also be based on the chance of being cured or the chance that the cancer will come back. Childhood cancer risk groups are used to plan treatment and follow-up care for certain types of cancer, such as neuroblastoma and rhabdomyosarcoma. Risk groups may be described as low risk, intermediate risk, or high risk.
A group of clinical cancer research organizations that get support from the National Cancer Institute to study childhood cancers. The main goal of Children's Oncology Group is to conduct clinical trials of new treatments for childhood and adolescent cancers at cancer centers in the United States, Canada, Europe, and Australia. Also called COG.
One of a pair of chromosomes that is part of the 46 chromosomes found in the nucleus of most human cells. Specific changes in chromosome 3 may be found in patients with certain genetic conditions or some types of cancer, including bladder cancer. Checking for these changes may help diagnose cancer or find out if cancer has come back. Chromosome 3 is a type of tumor marker.
One of a pair of chromosomes that is part of the 46 chromosomes found in the nucleus of most human cells. Specific changes in chromosome 17 may be found in patients with certain genetic conditions and some types of cancer, including bladder cancer, brain cancer, and leukemia. Checking for these changes may help diagnose cancer or find out if cancer has come back. Chromosome 17 is a type of tumor marker.
One of a pair of chromosomes that is part of the 46 chromosomes found in the nucleus of most human cells. Specific changes in chromosome 7 may be found in patients with certain genetic conditions or some types of cancer, including bladder cancer, leukemia, and lymphoma. Checking for these changes may help diagnose cancer or find out if cancer has come back. Chromosome 7 is a type of tumor marker.
Thread-like structures that hold all the genes. Except for sperm and egg cells, each human cell carries 23 pairs of chromosomes. In total, each person’s cells have 46 chromosomes, 23 come from the mother and 23 come from the father.
A disease or condition that persists or progresses over a long period of time.
An indolent (slow-growing) cancer in which too many myeloblasts are found in the blood and bone marrow. Myeloblasts are a type of immature blood cell that makes white blood cells called myeloid cells. Chronic myeloid leukemia may get worse over time as the number of myeloblasts increases in the blood and bone marrow. This may cause fever, fatigue, easy bleeding, anemia, infection, a swollen spleen, bone pain, or other signs and symptoms. Chronic myeloid leukemia is usually marked by a chromosome change called the Philadelphia chromosome, in which a piece of chromosome 9 and a piece of chromosome 22 break off and trade places with each other. It usually occurs in older adults and rarely occurs in children. Also called chronic granulocytic leukemia, chronic myelogenous leukemia, and CML.
In the body, the flow of blood through the heart and blood vessels, and the flow of lymph through the lymph vessels.
The system that contains the heart and the blood vessels and moves blood throughout the body. This system helps tissues get enough oxygen and nutrients, and it helps them get rid of waste products. The lymph system, which connects with the blood system, is often considered part of the circulatory system.
A drug used to treat certain types of bladder, ovarian, and testicular cancer. It is used in patients whose cancer cannot be treated with or has not gotten better with other anticancer treatment. It is also being studied in the treatment of other types of cancer. Cisplatin contains the metal platinum. It kills cancer cells by damaging their DNA and stopping them from dividing. Cisplatin is a type of DNA crosslinking agent. The brand name Platinol has been taken off the market and is no longer available.
In general, pertaining to observation and treatment of patients.
A health professional who works directly with patients, or uses data from patients, to do research on health and disease and to develop new treatments. Clinical researchers may also do research on how health care practices affect health and disease.
The failure of a cancer to shrink after treatment.
A case series in which the patients receive treatment in a clinic or other medical facility.
The stage of cancer (amount or spread of cancer in the body) that is based on tests that are done before surgery. These include physical exams, imaging tests, laboratory tests (such as blood tests), and biopsies.
A type of research study that tests how well new medical approaches work in people. These studies test new methods of screening, prevention, diagnosis, or treatment of a disease. Also called clinical trial.
A part of the clinical research process that answers specific questions about whether treatments that are being studied work and are safe. Phase I trials test the best way to give a new treatment and the best dose. Phase II trials test whether a new treatment has an effect on the disease. Phase III trials compare the results of people taking a new treatment with the results of people taking the standard treatment. Phase IV trials are done using thousands of people after a treatment has been approved and marketed, to check for side effects that were not seen in the phase III trial.
A person, company, institution, group, or organization that oversees or pays for a clinical trial and collects and analyzes the data. Also called trial sponsor.
A type of research study that tests how well new medical approaches work in people. These studies test new methods of screening, prevention, diagnosis, or treatment of a disease. Also called clinical study.
A health professional who takes care of patients.
A group of individuals who share a common trait, such as birth year. In medicine, a cohort is a group that is part of a clinical trial or study and is observed over a period of time.
A research study that compares a particular outcome (such as lung cancer) in groups of individuals who are alike in many ways but differ by a certain characteristic (for example, female nurses who smoke compared with those who do not smoke).
The longest part of the large intestine, which is a tube-like organ connected to the small intestine at one end and the anus at the other. The colon removes water and some nutrients and electrolytes from partially digested food. The remaining material, solid waste called stool, moves through the colon to the rectum and leaves the body through the anus.
Examination of the inside of the colon using a colonoscope, inserted into the rectum. A colonoscope is a thin, tube-like instrument with a light and a lens for viewing. It may also have a tool to remove tissue to be checked under a microscope for signs of disease.
Types of growth factors that promote growth and division of blood-producing cells in the bone marrow. CSFs are naturally produced in the body but extra amounts may be given as a treatment to reduce or prevent certain side effects of chemotherapy due to not having enough blood cells.
Cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine before the anus).
Therapy that combines more than one method of treatment. Also called multimodality therapy and multimodality treatment.
Care given to improve the quality of life of patients who have a serious or life-threatening disease. The goal of comfort care is to prevent or treat as early as possible the symptoms of a disease, side effects caused by treatment of a disease, and psychological, social, and spiritual problems related to a disease or its treatment. Also called palliative care, supportive care, and symptom management.
Therapies used in addition to conventional therapy. Some complementary therapies may help relieve certain symptoms of cancer, relieve side effects of conventional cancer therapy, or improve a patient's sense of well-being.
An examination of your blood that enables doctors to follow the course of your disease and to select the proper dosage of the appropriate chemotherapeutic drug. White blood count (WBC) refers to the number of leucocytes per cubic millimeter present in your peripheral blood. ""Diff"" (differential count) refers to the distribution of the various types of white cells in the peripheral blood; the values are expressed in percentages. Platelet count refers to the number or quantity of platelets per cubic millimeter present in your peripheral blood. Hemoglobin refers to the substance that carries oxygen to other tissues of the body. It is expressed as a percentage of total blood weight. Hematocrit refers to the packed volume of red cells separated from the plasma when whole blood is centrifuged (spun). It is expressed as a percentage. ""Retic"" (reticulocyte count) refers to the percentage of young, non-nucleated erythrocytes present in your peripheral blood.
The disappearance of all signs of cancer in response to treatment. This does not always mean the cancer has been cured.
The act of following a medical regimen or schedule correctly and consistently, including taking medicines or following a diet.
In medicine, a medical problem that occurs during a disease, or after a procedure or treatment. The complication may be caused by the disease, procedure, or treatment or may be unrelated to them.
A cancer research center that gets support from the National Cancer Institute (NCI) to do cancer research and provide services directly to cancer patients. Scientists and doctors at these centers do basic laboratory research and clinical trials, and they study the patterns, causes, and control of cancer in groups of people. Also, they take part in multicenter clinical trials, which enroll patients from many parts of the country. Comprehensive Cancer Centers also give cancer information to health care professionals and the public.
A cancer research center that gets support from the National Cancer Institute (NCI). Scientists and doctors at these centers do basic laboratory research and clinical trials on childhood cancers, and they study the patterns, causes, and control of cancer in groups of children. Also, they treat patients from many parts of the country and give cancer information to health care professionals and the public.
A pressing or squeezing together. In medicine, it can describe a structure, such as a tumor, that presses on another part of the body, such as a nerve. It can also describe the flattening of soft tissue, such as the breast, that occurs during a mammogram (x-ray of the breast).
A procedure that uses a computer linked to an x-ray machine to make a series of detailed pictures of areas inside the body. The pictures are taken from different angles and are used to create 3-dimensional (3-D) views of tissues and organs. A dye may be injected into a vein or swallowed to help the tissues and organs show up more clearly. A computerized tomography may be used to help diagnose disease, plan treatment, or find out how well treatment is working.
A treatment that is given at the same time as another.
A procedure in which a cone-shaped piece of abnormal tissue is removed from the cervix. A scalpel, a laser knife, or a thin wire loop heated by an electric current may be used to remove the tissue. The tissue is then checked under a microscope for signs of disease. Cone biopsy may be used to check for cervical cancer or to treat certain cervical conditions. Types of cone biopsy are LEEP (loop electrosurgical excision procedure) and cold knife conization (cold knife cone biopsy). Also called conization.
A condition or trait present at birth. It may be the result of genetic or non-genetic factors.
A condition in which the conjunctiva (membranes lining the eyelids and covering the white part of the eye) become inflamed or infected. Also called pinkeye.
A document with important information about a medical procedure or treatment, a clinical trial, or genetic testing. It also includes information on possible risks and benefits. If a person chooses to take part in the treatment, procedure, trial, or testing, he or she signs the form to give official consent.
A process in which patients are given important information, including possible risks and benefits, about a medical procedure or treatment, a clinical trial, or genetic testing. This is to help them decide if they want to be treated, tested, or take part in the trial. Patients are also given any new information that might affect their decision to continue.
Treatment that is given after cancer has disappeared following the initial therapy. Consolidation therapy is used to kill any cancer cells that may be left in the body. It may include radiation therapy, a stem cell transplant, or treatment with drugs that kill cancer cells.
A condition in which stool becomes hard, dry, and difficult to pass, and bowel movements don’t happen very often. Other symptoms may include painful bowel movements, and feeling bloated, uncomfortable, and sluggish.
The formal process of getting the opinion of a specialist.
Communicable through human contact.
A permanent tightening of the muscles, tendons, skin, and nearby tissues that causes the joints to shorten and become very stiff. This prevents normal movement of a joint or other body part. Contractures may be caused by injury, scarring, and nerve damage, or by not using the muscles. It may also occur at some point in time after a stem cell transplant that caused chronic graft-versus-host disease.
A symptom or medical condition that makes a particular treatment or procedure inadvisable because a person is likely to have a bad reaction. For example, having a bleeding disorder is a contraindication for taking aspirin because treatment with aspirin may cause excess bleeding.
Having to do with the opposite side of the body.
A dye or other substance that helps show abnormal areas inside the body. It is given by injection into a vein, by enema, or by mouth. Contrast material may be used with x-rays, CT scans, MRI, or other imaging tests.
In a clinical trial, the group that does not receive the new treatment being studied. This group is compared to the group that receives the new treatment, to see if the new treatment works.
A clinical study that includes a comparison (control) group. The comparison group receives a placebo, another treatment, or no treatment at all.
An experiment or clinical trial that includes a comparison (control) group.
A drug or other substance that is tightly controlled by the government because it may be abused or cause addiction. The control applies to the way the substance is made, used, handled, stored, and distributed. Controlled substances include opioids, stimulants, depressants, hallucinogens, and anabolic steroids. Controlled substances with known medical use, such as morphine, Valium, and Ritalin, are available only by prescription from a licensed medical professional. Other controlled substances, such as heroin and LSD, have no known medical use and are illegal in the United States.
A system in which medical doctors and other healthcare professionals (such as nurses, pharmacists, and therapists) treat symptoms and diseases using drugs, radiation, or surgery. Also called allopathic medicine, biomedicine, mainstream medicine, orthodox medicine, and Western medicine.
Treatment that is widely accepted and used by most healthcare professionals. It is different from alternative or complementary therapies, which are not as widely used. Examples of conventional therapy for cancer include chemotherapy, radiation therapy, and surgery. Also called conventional treatment.
A violent contraction and spasm of your muscles over which you have no control.
To adjust to new situations and overcome problems.
The methods a person uses to deal with stressful situations. These may help a person face a situation, take action, and be flexible and persistent in solving problems.
The removal of a tissue sample with a wide needle for examination under a microscope. Also called core needle biopsy.
Any steroid hormone made in the adrenal cortex (the outer part of the adrenal gland). They are also made in the laboratory. Corticosteroids have many different effects in the body, and are used to treat many different conditions. They may be used as hormone replacement, to suppress the immune system, and to treat some side effects of cancer and its treatment. Corticosteroids are also used to treat certain lymphomas and lymphoid leukemias.
A hormone made by the adrenal cortex (the outer layer of the adrenal gland). It helps the body use glucose (a sugar), protein, and fats. Cortisol made in the laboratory is called hydrocortisone. It is used to treat many conditions, including inflammation, allergies, and some cancers. Cortisol is a type of glucocorticoid hormone.
A rare, benign (not cancer) brain tumor that usually forms near the pituitary gland and the hypothalamus. Craniopharyngiomas are slow-growing and do not spread to other parts of the brain or to other parts of the body. However, they may grow and press on nearby parts of the brain, including the pituitary gland, hypothalamus, optic chiasm, optic nerves, and fluid-filled spaces in the brain. This may cause problems with growth, vision, and making certain hormones. Craniopharyngiomas usually occur in children and young adults.
A procedure using a sample of blood, urine, throat secretions or other biological material that determines the specific organism responsible for an infection. Cultures also help determine which antibiotics might be most effective.
In medicine, the total amount of a drug or radiation given to a patient over time; for example, the total dose of radiation given in a series of radiation treatments.
The total amount of a substance or radiation that a person is exposed to over time. Cumulative exposure to a harmful substance or radiation may increase the risk of certain diseases or conditions.
A measure of the total risk that a certain event will happen during a given period of time. In cancer research, it is the likelihood that a person who is free of a certain type of cancer will develop that cancer by a specific age. For example, a woman with no known risk factors for breast cancer has a cumulative risk of getting breast cancer over a lifetime of 90 years of about 12-13%. This means one out of every eight women will get breast cancer by age 90 years.
Surgery to remove all malignant (cancerous) tissue, which is meant to cure the disease. This includes removing part or all of the cancerous organ or tissue and a small amount of healthy tissue around it. Nearby lymph nodes may also be removed. Curative surgery works best for localized cancer. Chemotherapy or radiation therapy may be given before surgery to shrink the tumor or after surgery to kill any cancer cells that remain.
To heal or restore health; a treatment to restore health.
A blue appearance of the skin, lips and fingernails as a result of low oxygen content of the circulating blood.
A fluid filled sac of tissue; a cyst may be malignant or benign.
Inflammation of the urinary bladder.
The process of analyzing the number and shape of cell chromosomes.
A virus that may be carried in an inactive state for life by healthy individuals. It is a cause of severe pneumonia in people with a suppressed immune system, such as those undergoing bone marrow transplantation or those with leukemia or lymphoma. Also called CMV.