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Inotuzumab ozogamicin

Immunotherapy Monoclonal Antibody

Brand names:

Besponsa®

Often used for:

Acute lymphoblastic leukemia (ALL)

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What is Inotuzumab?

Inotuzumab is a type of medicine called a monoclonal antibody. This medicine works by attaching to a protein called CD22 found on some types of leukemia cells. When inotuzumab attaches to cells with CD22, it delivers a chemotherapy medicine called calicheamicin into the cell. Inotuzumab is considered a targeted therapy because the medicine is specific to certain cell features and “targets” those cells.

Blood pressure, heart rate, breathing, and temperature will be checked regularly during and after the infusion to watch for infusion-related side effects. 

Patients will have regular blood draws to check blood counts and monitor liver function. Heart function may also be monitored.

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Given as a liquid into a vein by IV

 
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Possible Side Effects

  • Flu-like symptoms (fever, chills)
  • Headache
  • Nausea or vomiting
  • Fatigue or weakness
  • Abdominal pain
  • Low blood counts (may cause increased risk of infection, bleeding, anemia and/or fatigue)
  • Liver problems
  • Kidney problems
  • Constipation
  • Diarrhea
  • Heart problems
  • Fertility problems
  • Tumor lysis syndrome
  • Infusion-related reactions: Symptoms may include chills, shortness of breath, coughing, dizziness, low blood pressure, pain in the chest, swelling of the face or neck

Not all patients who take inotuzumab will experience these side effects. Common side effects are in bold, but there may be others. Please report all suspected side effects to your doctor or pharmacist.

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Possible Late Effects

Some patients may experience long-term or late effects of treatment that may continue or develop months or years after treatment ends. Possible late effects due to inotuzumab include:

  • Fertility problems
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Tips for Families

Be sure to discuss these and other recommendations with your doctor or pharmacist.

  • Some patients may have a reaction to this medicine. Let a nurse know how you are feeling during the infusion.
  • Your care team may recommend diphenhydramine (Benadryl®), acetaminophen (Tylenol®), and a corticosteroid medicine to help prevent an infusion reaction or flu-like symptoms. 
  • Sexually active patients should take steps to prevent pregnancy during treatment and for 8 months after completion of therapy.
  • Patients should tell their doctor if they are pregnant or breastfeeding.

Inotuzumab resources